To stay healthy, our bodies must maintain a state of internal stability and be able to respond to environmental changes. When these cellular homeostasis mechanisms are disrupted, whether due to genetics or outside forces, it can lead to various diseases. In her Front Row lecture, Xiang-Lei Yang, Scripps Research professor and Ernest W. Hahn Chair, shares her research on an ancient family of proteins that evolved new functions to allow cellular communications to keep up with the ever-increasing complexity of the organisms. She also discusses some of the opportunities provided by the tRNA synthetase family in developing new therapies for neurodegenerative disorders, cancers and other diseases.

Presented: February 16, 2022

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